Single B Cell Antibody Discovery
Empowering Your Discovery with Precision, Speed, and Confidence
To overcome the limitations of traditional in vitro antibody display methods – particularly issues with chain pairing and antibody affinity – LxBio AB has adopted a Single B Cell Antibody Discovery platform. This platform screens and isolates individual antigen-specific plasma B cells to retrieve high-specificity, high-affinity antibody candidates. It is compatible with B cells from a wide range of species, including humans, rabbits, rats, mice, chickens, camelids, sheep, and even monkeys.
Discovery Workflow from Sample to Sequence in weeks
Adapted from: Going Beyond Simple Antibody Hit Generation in Opto® B Discovery with Relative Affinity Ranking for Soluble Antigens Brochure. 2023 Bruker Corporation . Website: brukercellularanalysis.com
- Target assessment & Sample preparation
- B Cell isolation & screening
- Real time clone characterization
- Candidate selection
Rapid Discovery
Speeds up the path from target identification to antibody development, streamlining therapeutic Antibody Discovery
Native paired heavy chain and light chain
Native pairing retains the natural immune response, increasing the chance of identifying potent antibodies
High specificity and stability in vivo
Maximizes the discovery of unique, high-affinity and stable antibodies by analysing vast antibody repertoires
Optimized for Complex Targets
Excels at discovering antibodies for challenging targets
Phage Display Antibody Discovery
If your Antibody Discovery process had already begun with in vitro display techniques, or if these are the most suitable techniques for your target or antibody format, LxBio also offers Phage Display services:
- From animal immunization to selection of the top clones, and everything in between.
- Extensive experience in phage display library creation.
- Different antibody formats: from the more standard formats such as IgG to VHH or ScFv, among others.
We understand your unique needs, whether you’re in an academic setting or advancing a product to clinical stage. Our scientists are committed to delivering a tailored antibody discovery service that aligns with your goals.
Headquarters
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